Can CBD Oil Cause Liver Toxicity?

It Could … If You Throw High Doses of a Mostly Non-absorbable CBD Form at Your Liver


The FDA has made the blanket statement that CBD can cause liver injury, even though the organization admits that it “has only seen limited data about CBD safety.”

Like many OTC and prescription drugs, CBD affects people differently. And yes, some limited studies have shown that very high doses of ingested CBD—that is CBD that is taken orally, processed through the digestive system, and metabolized by the liver—can cause liver toxicity. … You know, the way drugs like acetaminophen (Tylenol), alcohol, and even Vitamins A and niacin can cause liver toxicity if too much of them are consumed.

The FDA’s limited data consists of the University of Arkansas CBD extract mouse study and the Epidiolex clinical trials. In both of these studies, which the FDA alludes to, large doses of CBD, beyond the normal therapeutic range (.05 mg/kg to 20 mg/kg of CBD per day—the mice got the human equivalent of 200 mg/kg per day), were the cause of high levels of liver enzymes. Initially, when we read the Arkansas study here at The Hemp Haus, we were pretty ticked off. But a conversation with our trusted friend and chemist, Dr. Emek Blair of Puffin Hemp, assured us that the study did what science is supposed to do.

We Ask an Expert About CBD and Liver Toxicity

According to Dr. Blair, you are supposed to push the limits of a drug or supplement in order to understand where it may affect a small sensitive portion of the population and to know where the threshold between safety and risk exists. Dr. Blair also pointed out that these results were limited to CBD forms that had to be metabolized by the liver.

Its seems that from the limited evidence, so far—at least from the FDA—liver toxicity and CBD depend on three key factors: absorption, form, and dosage.

In this article, we’re going to take a look at how these three key factors come into play with liver toxicity and discuss the many other forms of CBD available that bypass potential liver toxicity for those of you that may be taking very high doses.

Keep in mind, although lots of preliminary research and anecdotal evidence exists, not nearly enough human studies have been done on cannabinoids. At The Hemp Haus, we talk about what we know so far from industry experts and how we and our clientele experience our high-quality cannabinoid products. 


High Doses of Ingested CBD and Liver Toxicity

At The Hemp Haus, we often recommend Ananda Hemp Full Spectrum CBD Softgels to our clientele for a constant level of CBD and whole-plant cannabis nutrients. It’s a low dose of CBD, meant to re-establish and maintain balance within the endocannabinoid system (ECS), similar to a daily vitamin.

For acute conditions, like breakthrough pain and panic attacks, we recommend more potent doses and forms of CBD, like Puffin Hemp Liposomal CBD, Ananda Hemp CBD Tinctures, or our Stardust Hemp Flower. One of the reasons for this is that CBD that has to be digested has poor bioavailability.

Studies show that typically only a small percentage of oral supplements get absorbed into the bloodstream. CBD is no different. Increasing the amount of CBD in an oral form that has to go through the digestive process only creates more work for your liver, which has to work to break down all the excess CBD that cannot be absorbed.

That’s why for the big jobs, we recommend CBD forms that bypass the liver.

We know this because we feature one of the most powerful, fastest-acting, highest-absorbing CBD products on the market. Puffin Hemp Liposomal CBD bypasses the liver and increases CBD bioavailability in the bloodstream by up to 20 percent.

Liposomes are nano-sized bubbles with an external shell made of healthy phospholipids (fats) and a hollow liquid center. These fat bubbles can be loaded with CBD to be delivered directly into your bloodstream. The healthy fats used for liposomes are the major building blocks of cell membranes. This means that the liposome that is delivering your nutrient package speaks the language of your body. It doesn’t need to get past the liver enzyme door-guy to gain access (or get denied).

Not only is Puffin Hemp the only scientifically proven liposomal CBD on the market, it’s the only liposomal hemp product to be used in a human clinical safety study of liposomal CBD.

Other products that have better absorption than regular oral CBD are sublingual tinctures and hemp flower that can be vaped or smoked. Sublingual tinctures go under your tongue and enter the bloodstream through your glands. We trust Ananda Hemp Full Spectrum Extract to get the job done. And any cannabis product that is inhaled enters through the lungs, which has been done by humans for centuries, by the way. We have curated our special line of Stardust Hemp Flower for anyone who wishes to go that route.

Unfortunately, the one CBD product the FDA approved was in the one form that depends on the liver to metabolize it.The truth is, there’s a real possibility that children taking CBD for severe forms of epilepsy most likely would not have to take as much if they had a liposomal form that performed like Puffin Hemp. The higher bioavailability would likely negate the need for such high doses and the liposomal form would eliminate the liver toxicity side effect.

This would make our friend and award-winning chemist Dr. Emek Blair—customizer of liposomes—a pretty significant player in the future of hemp CBD, don’t you think? We do.


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